Q: How does NAROPIN compare with bupivacaine in terms of motor function?
A: At equivalent concentrations of 0.5%, NAROPIN delivers faster return of motor function following C-sections than bupivacaine.1-3
Duration of Degree 1 Motor Block:
(Unable to flex hip, able to flex knee and ankle)
Duration of Degree 4 Motor Block:
(Complete motor paralysis, unable to move foot, knee, or toes)
NAROPIN delivers significantly faster return of motor function vs bupivacaine following brachial plexus nerve block for wrist and hand surgery.4
NAROPIN delivers faster return of motor function following lower extremity surgeries.5
Duration of Degree 1 Motor Block:
(Elective varicose vein or inguinal hernia surgery)
The low lipid solubility of NAROPIN gives it more selectivity for C sensory fibers, resulting in less interference with A motor fibers, which enables a faster return of motor function.6
Q: How does NAROPIN compare with bupivacaine for labor epidurals?
A: NAROPIN delivers significantly less motor block, resulting in more spontaneous vaginal deliveries and fewer instrumented deliveries than bupivacaine.7-9
Q: How does NAROPIN compare with bupivacaine in terms of analgesia?
A: At equivalent concentrations of 0.5%, NAROPIN offers onset, duration, and effectiveness of analgesia similar to bupivacaine in labor and delivery epidurals.1-3
At equal concentrations of 0.5%, the quality of analgesia was found to be similar between NAROPIN and bupivacaine following total knee replacement.10
NAROPIN provides sufficient analgesia with nonprogressive motor block in moderate to severe postoperative pain after major orthopedic surgery.11
Significantly more patients were satisfied with analgesic efficacy.12,13
Q: How does NAROPIN compare with bupivacaine in terms of the need for opioids?
A: NAROPIN has demonstrated a significant reduction in the need for opioids.9,12,14 In fact, only 10% of NAROPIN patients required opioids vs 23.3% of bupivacaine patients.12
Q: What are the key safety advantages of NAROPIN compared with bupivacaine?
A: The most serious safety concerns surrounding the use of local anesthetics involve the cardiovascular and central nervous system. Based on clinical pharmacologic studies, NAROPIN has less risk of cardiotoxicity—ie, significantly less depression of cardiac conductivity (less QRS widening)—as compared to bupivacaine. This cardiovascular depression profile provides an advantage in the event that an inadvertent intravascular injection occurs.15,16
In IV toxicity studies, severity and frequency of CNS symptoms were greater with bupivacaine than NAROPIN.15,16 In fact, recovery from CNS symptoms was 7 minutes shorter with NAROPIN than with bupivacaine (13 min vs 20 min, P<0.05, n=12).16
Q: What are common (≥5%) side effects reported when using NAROPIN?
A: Like all amide-type anesthetics, NAROPIN may be associated with adverse reactions. In clinical trials, side effects were mild and transient and may reflect the procedures, patient health status, and/or other medications used. Adverse events reported at a rate of ≥5%: hypotension, nausea, vomiting, bradycardia, fever, pain, postoperative complications, anemia, parasthesia, headache, pruritis, and back pain.9
Q: What are the recommended concentration, dose, and infusion rates of NAROPIN for its indicated uses?
A: Please see dosing card below.
Q: What concentrations of NAROPIN are available?
A: The following concentrations of NAROPIN are available:
2.0 mg/mL (0.2%)
5.0 mg/mL (0.5%)
10.0 mg/mL (1.0%)
Solutions of NAROPIN are available in a range of dosage forms:
Polyamp DuoFit® ampules
Q: What are the advantages of infusion bottles?
A: Infusion bottles are ideal for prolonged administration, making them convenient and cost-effective for postoperative pain management and labor pain management. They reduce the errors associated with dosing and premixing. Since mixing is not required, they also save time and labor costs, and ensure that sterility is maintained throughout use.
Q: What are Polyamp DuoFit® ampules?
A: Polyamp DuoFit® are polypropylene ampules that are designed for needle-free draw up, offering protection from glass shards, needles, and latex. The easy twist-off cap prevents cuts from sharp bands found on vials. Polyamp DuoFit® ampules are compatible with Luer-Lok® and tapered syringes, and are available in individual Sterile-Pak outer packaging. The Sterile-Pak enables Polyamp DuoFit® to be placed directly into the sterile field. Luer-Lok® is a registered trademark of Becton, Dickinson and Company.
NAROPIN is indicated for the production of local or regional anesthesia for surgery and for acute pain management.